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Makoto Emoto Selected Research

O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)

8/2011Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts.
4/2010Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent.
6/2007Antitumor effect of TNP-470, an angiogenesis inhibitor, combined with ultrasound irradiation for human uterine sarcoma xenografts evaluated using contrast color Doppler ultrasound.
3/2005The combination of Jun N-terminal kinase inhibitor and TNP-470 blocks carcinosarcoma-induced endothelial cell tube formation in a synergistic manner.
1/2004Carcinosarcoma-induced endothelial cells tube formation through KDR/Flk-1 is blocked by TNP-470.
4/2003Effect of angiogenesis inhibitor TNP-470 on the growth, blood flow, and microvessel density in xenografts of human uterine carcinosarcoma in nude mice.

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Makoto Emoto Research Topics

Disease

16Neoplasms (Cancer)
09/2015 - 04/2003
8Carcinosarcoma
09/2015 - 04/2003
5Sarcoma (Soft Tissue Sarcoma)
04/2014 - 12/2004
3Endometrial Neoplasms (Endometrial Cancer)
12/2010 - 04/2003
3Breast Neoplasms (Breast Cancer)
08/2009 - 11/2003
2Body Weight (Weight, Body)
09/2015 - 04/2010
2Carcinoma (Carcinomatosis)
12/2004 - 04/2003
2Endometrial Hyperplasia
11/2003 - 04/2003
1Hemorrhage
08/2011
1Leiomyosarcoma
04/2010
1Neoplasm Metastasis (Metastasis)
04/2010
1Fibrosis (Cirrhosis)
08/2009
1Cysts
08/2009
1Endometriosis
08/2009
1Nausea
07/2008
1Vomiting
07/2008
1Ovarian Cysts (Ovarian Cyst)
03/2006
1Polyps
11/2003
1Ovarian Neoplasms (Ovarian Cancer)
10/2003
1Ataxia (Dyssynergia)
04/2003
1Lymphatic Metastasis
04/2003
1Weight Loss (Weight Reduction)
04/2003

Drug/Important Bio-Agent (IBA)

6O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA
08/2011 - 04/2003
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2014 - 04/2003
3Angiogenesis InhibitorsIBA
04/2014 - 04/2003
3TamoxifenFDA LinkGeneric
08/2009 - 11/2003
2calcium phosphateIBA
09/2015 - 04/2010
2Pharmaceutical PreparationsIBA
04/2014 - 04/2003
2DNA (Deoxyribonucleic Acid)IBA
08/2009 - 11/2003
2Contrast MediaIBA
06/2007 - 10/2003
14-chlorophenyl methyl sulfide (CPMS)IBA
09/2015
1azaspireneIBA
05/2015
1Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
04/2014
1Biological ProductsIBA
04/2014
1Thrombospondin 1IBA
04/2014
1Liposomes (Liposome)IBA
01/2013
1Estrogens (Estrogen)FDA Link
10/2011
1Membrane Glycoproteins (Membrane Glycoprotein)IBA
10/2011
1Epithelial Cell Adhesion MoleculeIBA
10/2011
1VimentinIBA
10/2011
1Progesterone Receptors (Progesterone Receptor)IBA
10/2011
1doxifluridineIBA
08/2011
1Biomarkers (Surrogate Marker)IBA
02/2011
1Irinotecan (Camptosar)FDA LinkGeneric
02/2011
1Danazol (Azol)FDA LinkGeneric
08/2009
1Gonadotropin-Releasing Hormone (GnRH)FDA Link
08/2009
1Docetaxel (Taxotere)FDA Link
07/2008
15-HT3 Serotonin Receptors (5 HT3 Receptor)IBA
07/2008
1indisetron hydrochlorideIBA
07/2008
1Carboplatin (JM8)FDA LinkGeneric
07/2008
1Paclitaxel (Taxol)FDA LinkGeneric
07/2008
1Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric
03/2006
1JNK Mitogen-Activated Protein KinasesIBA
03/2005
1Vascular Endothelial Growth FactorsIBA
12/2004
1Messenger RNA (mRNA)IBA
12/2004
1AngiopoietinsIBA
12/2004
1Codon (Codons)IBA
11/2003
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
04/2003
1Vascular Endothelial Growth Factor DIBA
04/2003
1Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA
04/2003
1fumagillinIBA
04/2003

Therapy/Procedure

8Therapeutics
04/2014 - 04/2003
6Radiotherapy
09/2015 - 04/2003
5Drug Therapy (Chemotherapy)
05/2015 - 07/2008
2Microspheres (Microsphere)
09/2015 - 04/2010
2Microbubbles
06/2007 - 10/2003
1Lasers (Laser)
08/2011
1Hysterectomy
12/2010
1Laparotomy
04/2010
1Aftercare (After-Treatment)
04/2010
1Cystectomy
08/2009